Manual acupuncture relieves microglia-mediated neuroinflammation in a rat model of traumatic brain injury by inhibiting the RhoA/ROCK2 pathway.
Ming-Min ZhuJi-Huan LinPeng QingLiu PuShu-Lian ChenShu-Jun LinCheng-Lu LiLu-Xi CaoYi-Min ZhangPublished in: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2020)
These results show that MA may inhibit M1 polarization of microglia by regulating the RhoA/ROCK2 signaling pathway, thereby reducing neuroinflammation in TBI.
Keyphrases
- signaling pathway
- traumatic brain injury
- inflammatory response
- lipopolysaccharide induced
- lps induced
- cerebral ischemia
- neuropathic pain
- spinal cord injury
- pi k akt
- cognitive impairment
- epithelial mesenchymal transition
- white matter
- induced apoptosis
- resting state
- subarachnoid hemorrhage
- severe traumatic brain injury
- spinal cord
- blood brain barrier
- brain injury
- oxidative stress
- functional connectivity
- mild traumatic brain injury
- cell proliferation