Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism.

Leena KadamMarija VeličkovićKelly StrattonCarrie D NicoraJennifer E KyleEric WangMatthew E MonroeLisa M BramerLeslie MyattKristin E Burnum-Johnson

Published in: bioRxiv : the preprint server for biology (2024)

This is the first study assessing fatty acid composition of lipids in matched maternal plasma and placental tissue from lean, obese, and GDM women stratified by fetal sex. It highlights how GDM affects distribution of fatty acids in lipid classes changes in a sexually dimorphic manner in the placenta.

Keyphrases

fatty acid
pregnancy outcomes
weight loss
metabolic syndrome
birth weight
type diabetes
pregnant women
insulin resistance
weight gain
adipose tissue
polycystic ovary syndrome
mental health
skeletal muscle