Levothyroxine initiation and the risk of pregnancy loss among pregnant women with subclinical hypothyroidism: An observational study emulating a target trial.
Sonia Marzia GrandiYa-Hui YuPauline ReynierRobert W PlattOriana Hoi Yun YuKristian B FilionPublished in: Paediatric and perinatal epidemiology (2023)
Although our assessment of the effect of initiation of levothyroxine for SCH in pregnancy precludes any definitive conclusions due to wide confidence intervals, this study illustrates the feasibility of using the target trial emulation framework to examine the effectiveness of medication use in pregnancy.