Differential DNA methylation and CTCF binding between the ESR1 promoter a of MCF-7 and MDA-MB-231 breast cancer cells.
Edén Víctor Montes-de-Oca-FuentesKarina Jácome-LópezAnaís Zarco-MendozaGeorgina GuerreroJosé Luis Ventura-GallegosSergio Juárez-MéndezAlberto Jose Cabrera-QuinteroFélix Recillas-TargaAlejandro Zentella-DehesaPublished in: Molecular biology reports (2024)
ESR1 expression in MCF7 cells is dependent on CTCF expression. CTCF can bind to specific regions of the promotor of ESR1 gene in MCF-7 cells but not in MDA-MB-231 cells, this correlates with the methylation status of these regions and could be involved in the transcriptional regulation of ESR1.
Keyphrases
- breast cancer cells
- cell cycle arrest
- induced apoptosis
- dna methylation
- genome wide
- estrogen receptor
- poor prognosis
- gene expression
- cell death
- endoplasmic reticulum stress
- signaling pathway
- transcription factor
- cell proliferation
- pi k akt
- long non coding rna
- copy number
- dna binding
- genome wide identification
- genome wide analysis