Methylglyoxal Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via RAGE-Induced ROS Generation: Protective Effects of Metformin.
Matheus L MedeirosAkila L OliveiraMariana G de OliveiraFabíola Z MónicaEdson AntunesPublished in: Journal of inflammation research (2021)
MGO intake potentiates the LPS-induced ALI, increases RAGE expression and ROS generation, which is normalized by metformin. MGO scavengers may be a good adjuvant therapy to reduce ALI in patients with cardiometabolic diseases.