Methylglyoxal Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via RAGE-Induced ROS Generation: Protective Effects of Metformin.

Matheus L MedeirosAkila L OliveiraMariana G de OliveiraFabíola Z MónicaEdson Antunes

Published in: Journal of inflammation research (2021)

MGO intake potentiates the LPS-induced ALI, increases RAGE expression and ROS generation, which is normalized by metformin. MGO scavengers may be a good adjuvant therapy to reduce ALI in patients with cardiometabolic diseases.

Keyphrases

lipopolysaccharide induced
inflammatory response
lps induced
cell death
dna damage
reactive oxygen species
poor prognosis
high glucose
diabetic rats
oxidative stress
drug induced
binding protein
weight gain
endothelial cells
long non coding rna
body mass index