Novel Therapeutic Mechanism of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis via Upregulation of BTG2.

Qinyan YangLi JinQian DingWei HuHaiBo ZouMingming XiaoKeyuan ChenYue YuJin ShangXiaolun Huang Qiu-Yan Zhang

Published in: Oxidative medicine and cellular longevity (2022)

AD-MSCs suppresses OA progression through KLF4-induced transcriptional activation of BTG2. Our findings revealed an AD-MSCs-dominated therapeutic method for OA.

Keyphrases

mesenchymal stem cells
umbilical cord
knee osteoarthritis
signaling pathway
bone marrow
transcription factor
gene expression
rheumatoid arthritis
cell therapy
diabetic rats
cell proliferation
poor prognosis
single cell
drug induced
stem cells
heat shock