An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration.

Virginia Tajadura-OrtegaRitu GargRichard AllenClaudia OwczarekMichael D BrightSamuel KeanAisyah Mohd-NoorAnita GrigoriadisTimothy C ElstonKlaus M HahnAnne J Ridley

Published in: BMC biology (2018)

We describe a novel role for RhoH in prostate cancer cell migration. We propose that RhoH promotes cell migration by coupling Rac1 activity and PAK2 to membrane protrusion. Our results also suggest that RhoH expression levels correlate with prostate cancer progression.

Keyphrases

cell migration
prostate cancer
radical prostatectomy
poor prognosis
transcription factor
gene expression
binding protein
single cell