UHRF1 Induces Metastasis in Thyroid Cancer.

Bo-Hua KuangGuo-He LinQuentin LiuBi-Cheng Wang

Published in: Journal of oncology (2022)

Our results suggest that UHRF1 could induce the metastasis of thyroid cancer, and the potential signaling pathway might be that UHRF1 activates c-Jun/AP-1 to increase the expression of IL-6 and MIF. These findings provide a novel mechanism of UHRF1 and illustrate that UHRF1/AP-1 complex could be a potential therapeutic target for patients with thyroid cancer.

Keyphrases

signaling pathway
transcription factor
poor prognosis
epithelial mesenchymal transition
pi k akt
oxidative stress
cell proliferation
risk assessment