Natural history of spinal cord compression stage AFMS3 in infants with achondroplasia: retrospective cohort study.
Moira Shang-Mei CheungAlessandra CoccaCharlotte H HarveyConnor Stephen S BrettAmaka C OffiahStephanie BorgNathan JenkoFelice D'ArcoDominic ThompsonPublished in: Archives of disease in childhood (2024)
These results support MRI screening for FMS in infants with achondroplasia. Furthermore, infants with AFMS3 should undergo follow-up MRI as over 40% progress prompting neurosurgical intervention. There is currently no consensus on frequency or timing of screening for AFMS3 in achondroplasia; however, we suggest that guidance for follow-up imaging is modified to 6 months to detect progression earlier in this at-risk cohort.