Cognitive Functions in Adult-Onset Phenotypes of X-Linked Adrenoleukodystrophy.
Lisa SchäferHannes RoickeMartin FischerAnnett SühnelWolfgang KöhlerPublished in: Annals of neurology (2021)
Cerebral demyelination in patients with X-ALD causes white matter dementia, mainly characterized by an extreme slowdown in processing speed associated with deficits in attention and learning. Most patients with AMN show intact cognitive function. Future prospective, longitudinal studies with more sensitive imaging techniques are required to clarify whether early mild cognitive dysfunction found in some patients with AMN may be associated with subtle myelin abnormalities that do not yet appear as white matter lesions on cerebral MRI (cMRI) but have the potential to serve as early predictors of later cerebral progression. ANN NEUROL 2021;90:266-273.
Keyphrases
- white matter
- subarachnoid hemorrhage
- multiple sclerosis
- cerebral ischemia
- high resolution
- magnetic resonance imaging
- working memory
- mild cognitive impairment
- brain injury
- cross sectional
- climate change
- contrast enhanced
- cognitive impairment
- blood brain barrier
- current status
- photodynamic therapy
- human health
- computed tomography
- case control
- fluorescence imaging