Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia type 2B brain lesions.
Victoria-Elisabeth GruberMark J LuinenburgKatrin ColleselliVerena EndmayrJasper J AninkTill S ZimmerFloor JansenPeter GosselaarRoland CorasTheresa SchollIngmar BluemckeJosé PimentelJohannes A HainfellnerRomana HöftbergerKarl RösslerMartha FeuchtJackelien van ScheppingenEleonora AronicaAngelika MühlebnerPublished in: Epilepsia (2021)
Our results demonstrate that the prominent activation of the complement pathway represents a common pathological hallmark of TSC and FCD2B, suggesting that complement overactivation may play a role in these mTORopathies.