Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.

C. Simon HerringtonAilsa J OswaldLorna J StillieIan CroyMichael ChurchmanRobert L Hollis

Published in: British journal of cancer (2023)

CCNE1 gain and chrX loss are frequent in OCS. SRC gain, increased GNAS expression and microRNA dysregulation represent potential mechanisms driving sarcomatous compartment formation.

Keyphrases

tyrosine kinase
poor prognosis
genome wide
single cell
binding protein
human health
long non coding rna
risk assessment
gene expression