Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration.
Yue FanXuzhao BianXiaogao MengLei LiLaiyi FuYanan ZhangLong WangYan ZhangDalong GaoXiong GuoMikko Juhani LammiGuangdun PengShiquan SunPublished in: Annals of the rheumatic diseases (2024)
Our results highlight InfC, preHTC, preFC and HTC as potential cell populations to target for therapy. Also, we conclude that profiling of those cell populations in patients might be used to stratify patient populations for defining cohorts for clinical trials and precision medicine.
Keyphrases
- single cell
- cell therapy
- clinical trial
- end stage renal disease
- ejection fraction
- oxidative stress
- chronic kidney disease
- total knee arthroplasty
- randomized controlled trial
- prognostic factors
- risk assessment
- bone marrow
- mesenchymal stem cells
- big data
- climate change
- patient reported outcomes
- human health
- data analysis