IMMUNOREACT 6: weak immune surveillance characterizes early-onset rectal cancer.
Salvatore PucciarelliAngelo Paolo Dei TosMelania ScarpaAstghik StepanyanOttavia De SimoniFederico ScognamiglioValentina ChiminazzoClarissa De NardiGiulia TamponiSilvia NegroImerio AngrimanAndromachi KotsaftiCesare RuffoloChiara VignottoMaurizio ZizzoFrancesco MarchegianiLuca FacciFrancesca BergamoStefano BrignolaGianluca BusinelloVincenza GuzzardoLuca Dal SantoRoberta SalmasoCarlotta CecconMarco MassaniAnna PozzaIvana CataldoTommaso SteccaAngelo Paolo Dei TosVittorina ZagonelPierluigi PilatiBoris FranzatoAntonio ScapinelloGiovanni PirozzoloAlfonso RecordareRoberto MerendaGiovanni BordignonLicia LaurinoSilvio GuerrieroChiara RomitiGiuseppe PortaleChiara CipollariSalvatore CandioliLaura GavagnaGiulia PozzaMario GodinaIsabella MondiGiulia NoaroMonica OrtenziMario GuerrieriGiovanni TaglienteMonica TomassiUmberto TedeschiAndrea PorzionatoMarco AgostiniSalvatore PucciarelliQuoc Riccardo BaoFrancesco CavallinBarbara Di CamilloRomeo BardiniIgnazio CastagliuoloSalvatore PucciarelliMelania Scarpanull nullPublished in: The British journal of surgery (2023)
Early-onset rectal cancer is rarely associated with common hereditary syndromes. The tumour microenvironment is characterized by a high frequency of mutations impairing the local immune surveillance mechanisms and low expression of immune editing-related genes. A constitutively low number of CD4 T cells associated with a high number of T regulators indicates an imbalance in the immune surveillance mechanisms.