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Expression of discoidin domain receptor 1 and E-cadherin in epidermis affects melanocyte behavior in rhododendrol-induced leukoderma mouse model.

Yuko AbeYutaka HozumiKen OkamuraTamio Suzuki
Published in: The Journal of dermatology (2020)
Vitiligo is a depigmentation disease characterized by gradual loss of melanin and melanocytes from the epidermis. The mechanism of melanocyte loss is not yet known. In this report, we showed that the expression of discoidin domain receptor 1 and E-cadherin, known adhesion molecules, was variable or absent in the epidermis of rhododendrol-induced leukoderma (RDIL) mice during the depigmentation process. Our findings suggest that melanocyte damage by rhododendrol promotes reduction of adhesion molecules not only in melanocytes but also in keratinocytes, and this is associated with the detachment of melanocytes from the basal layer.
Keyphrases
  • poor prognosis
  • high glucose
  • mouse model
  • diabetic rats
  • binding protein
  • oxidative stress
  • endothelial cells
  • biofilm formation
  • escherichia coli
  • metabolic syndrome
  • pseudomonas aeruginosa