Incremental Elevations in TNFα and IL6 in the Human Colon and Procancerous Changes in the Mucosal Transcriptome Accompany Adiposity.
Anna C PfalzerKeith LeungJimmy W CrottSusan J KimAlbert K TaiLaurence D ParnellFrederick K KamanuZhenhua LiuGail RogersM Kyla SheaPaloma E GarciaJoel B MasonPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2018)
These observations delineate means by which an inflammatory milieu may contribute to obesity-promoted colon cancer.
Keyphrases
- insulin resistance
- endothelial cells
- weight gain
- metabolic syndrome
- rheumatoid arthritis
- weight loss
- type diabetes
- induced pluripotent stem cells
- rna seq
- gene expression
- oxidative stress
- single cell
- high fat diet induced
- pluripotent stem cells
- genome wide
- body mass index
- skeletal muscle
- ulcerative colitis
- physical activity
- dna methylation