Fraction Dose Escalation of Hypofractionated Radiotherapy with Concurrent Chemotherapy and Subsequent Consolidation Immunotherapy in Locally Advanced Non-Small Cell Lung Cancer: A Phase I Study.

Rui Zhou FangJie Liu HongMei Zhang DaQuan Wang PengXin Zhang Shiyang Zheng YiMei Liu Li Chen JinYu Guo YingYi Zou Yu-Ming Rong Hui Liu Bo Qiu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Utilizing the split-course hypo-RT and hypoboost approach, a fraction dose of 5 Gy to a total dose of 60 Gy, combined with concurrent chemotherapy and subsequent cICI, was well tolerated and yielded a promising objective response rate and survival outcomes.

Keyphrases

locally advanced
advanced non small cell lung cancer
radiation therapy
rectal cancer
squamous cell carcinoma
epidermal growth factor receptor
early stage
randomized controlled trial
open label
clinical trial
small cell lung cancer
chemotherapy induced