Regional brain glucose metabolism is differentially affected by ketogenic diet: a human semiquantitative positron emission tomography.
Tatiana HorowitzEmilie DocheMary PhilipSerge CammilleriLaurent SuissaEric GuedjPublished in: European journal of nuclear medicine and molecular imaging (2023)
KD globally reduces brain glucose metabolism but with regional differences, requiring special attention to clinical interpretation. On a pathophysiological perspective, these findings could help understand underlying neurological effects of KD through possible decrease of oxidative stress in posterior regions and functional compensation in the limbic regions.
Keyphrases
- positron emission tomography
- computed tomography
- oxidative stress
- resting state
- white matter
- endothelial cells
- cerebral ischemia
- functional connectivity
- pet imaging
- dna damage
- physical activity
- working memory
- induced pluripotent stem cells
- ischemia reperfusion injury
- multiple sclerosis
- subarachnoid hemorrhage
- pluripotent stem cells
- induced apoptosis
- diabetic rats