Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT).
Suzie CroV R CorneliusA E PinkR WilsonA Pushpa-RajahP PatelA Abdul-WahabS AugustJ AzadG BecherA ChapmanG DunnilA D FergusonA FogoS A GhaffarJohn R IngramS KavakleivaE LadoyanniJ A LemanA E MacbethA MakrygeoegouR ParslewA J RyanA SharmaAlexa R ShipmanC SinclairR WachsmuthR T WoolfA WrightH McAteerJ N W N BarkerA D BurdenChristopher Ernest Maitland GriffithsN J ReynoldsR B WarrenH J LachmannFrancesca CaponCatherine H Smithnull nullPublished in: The British journal of dermatology (2021)
No evidence for the superiority of anakinra was found. IL-1 blockade is not a useful intervention for the treatment of PPP.