Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control.
Maria E RodriguezIrantzu Serrano-MendiorozEneko Garate-SoraluzePaloma Sánchez-MateosCelia Barrio-AlonsoInmaculada Rodríguez LópezVictor Diaz PascualLeire Arbea MorenoMaite AlvarezMiguel F SanmamedJose Luis Perez-GraciaHelena Escuin-OrdinasMarisol QuinteroIgnacio Melero BermejoPublished in: Journal for immunotherapy of cancer (2023)
This study demonstrates that local BO-112 immunotherapy and focal irradiation may act in synergy to achieve local tumor control. Irradiation plus BO-112 in one of the tumor lesions enhanced the therapeutic effects on distant irradiated lesions that were not injected with BO-112, suggesting strategies to treat oligometastatic patients with lesions susceptible to radiotherapy and with at least one tumor accessible for repeated BO-112 intratumoral injections.