Bioavailability of dissolved and crushed single tablets of bictegravir, emtricitabine, tenofovir alafenamide in healthy adults: the SOLUBIC randomized crossover study.

Laurent HocquelouxSandrine LefeuvreJulie BoisSylvie BrucatoAntoine AlixCécile ValentinLaure Peyro-Saint-PaulLaurence GotFrançois FournelSylvie DargereThierry PrazuckAnna FournierNicolas GregoireIan McNichollJean-Jacques Parienti

Published in: The Journal of antimicrobial chemotherapy (2022)

Crushing BIC/TAF/FTC tablets may lead to suboptimal emtricitabine and tenofovir alafenamide drug exposures. Dissolving BIC/TAF/FTC in water may be acceptable if the tablet cannot be swallowed whole.

Keyphrases

antiretroviral therapy
double blind
open label
organic matter
air pollution
placebo controlled
phase iii
phase ii
clinical trial
emergency department
randomized controlled trial
adverse drug