Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients.
Adrienne Müller HerdeRoger SchibliMarkus WeberSimon M AmetameyPublished in: European journal of nuclear medicine and molecular imaging (2018)
LPS-induced neuroinflammation increased mGluR5 levels in mouse brain and is dependent on the mouse strain and time after LPS treatment. mGluR5 levels were also increased in human AD and ALS brains in vitro. PET imaging of mGluR5 levels could potentially be used to diagnose and monitor therapy outcomes in patients with AD and ALS.
Keyphrases
- lps induced
- inflammatory response
- pet imaging
- lipopolysaccharide induced
- amyotrophic lateral sclerosis
- endothelial cells
- end stage renal disease
- newly diagnosed
- ejection fraction
- prognostic factors
- type diabetes
- induced pluripotent stem cells
- mesenchymal stem cells
- combination therapy
- pluripotent stem cells
- smoking cessation