Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells.

Yuanming WangKaiwen Ivy LiuNorfala-Aliah Binte SutrisnohHarini SrinivasanJunyi ZhangJia LiFan ZhangCharles Richard John LalithHeyun XingRaghuvaran ShanmugamJia Nee FooHwee Ting YeoKean Hean OoiTore BleckwehlYi Yun Rachel ParShi Mun LeeNur Nadiah Binte IsmailNur Aidah Binti SanwariSi Ting Vanessa LeeJan LewMeng How Tan

Published in: Genome biology (2018)

Our work delineates design parameters for each CRISPR-Cas system and will serve as a useful reference for future genome engineering studies.

Keyphrases

crispr cas
genome editing
current status
genome wide
gene expression