Expression and prognostic role of E2F transcription factors in high-grade glioma.

Hai YuZhijin LiMaode Wang

Published in: CNS neuroscience & therapeutics (2020)

E2Fs (except for E2F3 and E2F5) are highly expressed in HGG and indicate adverse outcome. E2F7 and E2F8 were identified as novel potential prognostic markers in HGG. E2F7 was further validated to be closely associated with radioresistance of HGG and a critical transcriptional regulator of EZH2.

Keyphrases

transcription factor
high grade
poor prognosis
low grade
gene expression
long non coding rna
emergency department
human health
dna damage
adverse drug
dna repair