Alteration of splicing factors' expression during liver disease progression: impact on hepatocellular carcinoma outcome.

Hualin WangBouchra LekbabyNadim FaresJeremy AugustinTarik AttoutAurelie SchnurigerAnne-Marie CassardGanna PanasyukGabriel PerlemuterIvan BiecheSophie VacherJanick SelvesJean-Marie PéronBrigitte BancelPhilippe MerleDina KremsdorfJanet HallIsabelle CheminPatrick Soussan

Published in: Hepatology international (2019)

Dysregulation of SF expression is an early event occurring during liver injury and not just at the stage of HCC. Besides impacting on AS regulation, overexpression of SF may contribute to preserving hepatocyte homeostasis during liver pathogenesis.

Keyphrases

liver injury
drug induced
poor prognosis
binding protein
cell proliferation
long non coding rna