Assessment of the soluble proteins HMGB1, CD40L and CD62P during various platelet preparation processes and the storage of platelet concentrates: The BEST collaborative study.
Fabrice CognasseHind Hamzeh-CognasseMarie Ange EyraudAmélie PrierCharles Antoine ArthaudPierre TiberghienStephane BegueDirk de KorteEric GouwerokAndreas GreinacherKonstanze AurichFemke NoormanLarry J DumontKathleen K KellyMarc CloutierRenée BazinRebecca CardiganSian HuishPeter A SmethurstDana V DevinePeter SchubertLacey JohnsonDenese C Marksnull nullPublished in: Transfusion (2022)
The HMGB1 release mechanism/intracellular pathways appear to differ from sCD62P and sCD40L. The extent to which these differences affect patient outcomes, particularly post-transfusion platelet increment and adverse events, warrants further investigation in clinical trials with various therapeutic indications.