Higher expression of SALL4-A isoform is correlated with worse outcomes and progression of the disease in subtype of testicular germ cell tumours.
Niknam LakpourRoya GhodsMaryam AbolhasaniLeili Saeednejad ZanjaniKioomars SaliminejadElham KalantariSima SakiMohammad Mehdi RanjbarLeila Balay-GoliMohammad Reza SadeghiZahra MadjdPublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2024)
SALL4-A isoform expression in the cytoplasm and nucleus of TGCTs may be associated with histological differentiation. In the seminoma subtype of TGCTs, higher expression of SALL4-A may be used as a predictive indicator of poorer outcomes and prognosis.