High-trans fatty acid and high-sugar diets can cause mice with non-alcoholic steatohepatitis with liver fibrosis and potential pathogenesis.
Xin XinBei-Yu CaiCheng ChenHua-Jie TianXin WangYi-Yang HuQin FengPublished in: Nutrition & metabolism (2020)
After keeping 30 weeks HFHC diet treatment, the mice exhibited substantial liver fibrosis, hepatic steatosis, ballooning degeneration and inflammation. Basing on the transcriptome microarray assays, the experimental NASH involving liver fibrosis potentially related to dramatically changed ECM-receptor interaction, Toll-like receptor signaling and other signaling pathways.
Keyphrases
- liver fibrosis
- toll like receptor
- fatty acid
- high fat diet induced
- nuclear factor
- inflammatory response
- weight loss
- signaling pathway
- immune response
- oxidative stress
- physical activity
- gene expression
- single cell
- type diabetes
- genome wide
- gestational age
- skeletal muscle
- metabolic syndrome
- insulin resistance
- climate change
- human health
- extracellular matrix
- drug induced