Predicting Toxicity and Response to Pembrolizumab Through Germline Genomic HLA Class 1 Analysis.

Marco A J IafollaCindy YangVinod ChandranMelania PintilieQuan LiPhilippe L BedardAaron HansenStephanie LheureuxAnna SpreaficoAlbiruni A RazakSevan HakgorAmanda GieslerTrevor J PughLillian L Siu

Published in: JNCI cancer spectrum (2020)

HLA-C heterozygosity may predict decreased response to pembrolizumab. Prospective validation is required.

Keyphrases

advanced non small cell lung cancer
oxidative stress
copy number
gene expression
dna methylation