Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection.
Bani TamrazLori ReisnerAudrey L FrenchSamuel T KingMargaret A FischlIgho OfotokunAngela KashubaJoel MilamKerry MurphyMichael AugenbraunChenglong LiuPatrick R FinleyBradley AouizeratJennifer CocohobaStephen GangePeter BacchettiRuth M GreenblattPublished in: Pharmacotherapy (2019)
In this cohort of HIV-infected and at-risk HIV-uninfected women, use of benzodiazepines, CNS depressants, and conditional QTc interval-prolonging medications were associated with a higher risk of mortality independent of methadone and other well-recognized mortality risk factors. Care must be taken to assess risk when prescribing these medications in this underserved and at-risk patient population.
Keyphrases
- hiv infected
- risk factors
- antiretroviral therapy
- cardiovascular events
- polycystic ovary syndrome
- human immunodeficiency virus
- healthcare
- endothelial cells
- primary care
- hiv positive
- palliative care
- pregnancy outcomes
- emergency department
- skeletal muscle
- insulin resistance
- breast cancer risk
- pregnant women
- pain management
- induced pluripotent stem cells
- pluripotent stem cells