Optimal Treatment Parameters for Ultrasound-Stimulated Microbubbles in Upregulating Proliferation and Stemness of Bone Marrow Mesenchymal Stem Cells.

Beibei ChenQiong ZhuMao DuanQinglong LiGong WangXue GuanPu YuXiaoxun XuYing HeYali Xu

Published in: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine (2024)

In conclusion, the appropriate peak PNP value of UTMD was 1.5 MPa, and 1.5 MPa-mediated UTMD group obviously promoted MSCs proliferation and maintained stemness by upregulating the expression of stemness genes.

Keyphrases

stem cells
epithelial mesenchymal transition
signaling pathway
poor prognosis
cancer stem cells
mesenchymal stem cells
magnetic resonance imaging
genome wide
binding protein
combination therapy
bone marrow