CuBr-Catalyzed α-Arylation and Aerobic Oxidative Dehydrogenative C-N Coupling for the Synthesis of Spiro[cyclohexane-1,12'-isoindolo[1,2-b]quinazolin]-10'-one Derivatives.

A copper-catalyzed approach was disclosed for C(sp3)-C(sp2) bond formation via an α-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C(sp3)-N bond, wherein O2 served as a green oxidant. This protocol provided a domino method for the synthesis of spiro[cyclohexane-1,12'-isoindolo[1,2-b]quinazolin]-10'-ones containing a nitrogen-substituted quaternary carbon center.