Low-dose clonidine infusion to improve sleep in postoperative patients in the high-dependency unit. A randomised placebo-controlled single-centre trial.
David LiuElizabeth HalltAlanna PlatzAlain HumbletMelissa Lassig-SmithJanine StuartCheryl FourieAmelia LivermoreBree-Yana McConnochieTherese StarrKymberley HerbstChristine A WoodsJason M PincusMichael Charles ReadePublished in: Intensive care medicine (2024)
Among postoperative elective surgical patients admitted to HDU, low-dose non-titrated clonidine, compared to placebo, was associated with longer and subjectively better-quality sleep.
Keyphrases
- low dose
- placebo controlled
- double blind
- patients undergoing
- phase iii
- study protocol
- clinical trial
- end stage renal disease
- high dose
- phase ii
- ejection fraction
- open label
- physical activity
- newly diagnosed
- chronic kidney disease
- sleep quality
- peritoneal dialysis
- randomized controlled trial
- squamous cell carcinoma
- patient reported outcomes
- phase ii study