Radioresistance and genomic alterations in head and neck squamous cell cancer: Sub-analysis of the ProfiLER protocol.

Elise RowinskiNicolas Magné Jérôme Fayette Elisabeth DagunetSéverine RacadotPascal PommierBenoîte MéryAlexis VallardFabien TinquautEve-Marie Neidhardt-BerardPhilippe CassierValéry AttignonDaniel PissalouxQing WangEmilie SohierDavid PérolJean-Yves BlayOlivier Trédan

Published in: Head & neck (2021)

This sub analysis suggests that PIK3CA mutation, variation of copy number of MAP kinases and apoptosis pathways play a significant role in the radioresistance phenomenon.

Keyphrases

copy number
squamous cell
mitochondrial dna
genome wide
dna damage response
dna methylation
oxidative stress
randomized controlled trial
endoplasmic reticulum stress
cell cycle arrest
signaling pathway
young adults
data analysis