Investigation of YAP-1, OTX-2, and nestin protein expressions in neuroblastoma: a preliminary study.
Selen Kum ÖzşengezerZekiye Sultan AltunGamze SanlavBurçin BaranDeniz KizmazogluSafiye AktaşPembe KeskinogluHatice Nur OlgunPublished in: Annals of clinical and translational neurology (2024)
The findings of this study support that YAP-1 may be a potential prognostic biomarker for staging and risk-group assignment of NB patients. YAP-1 expression in neuroblastoma is associated with significantly poorer survival probabilities and should be considered as a potential therapeutic target. OTX-2 is a promising predictive biomarker candidate, but its mechanisms need further investigation in neuroblastoma, as nestin expression is not significantly linked to patient survival.