Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF.

Chen WangXinlu YuSai DingYang LiuHongxia ZhangJingbo FuBing YuHaiying Zhu

Published in: Cell & bioscience (2022)

The self-renewal of iHepSCs was maintained by the higher expression of Myc, which was coregulated by TET1 and CTCF. This study may provide new insights into the self-renewal of stem cells, which can promote the research and application of 'reprogrammed' stem cells.

Keyphrases

stem cells
poor prognosis
cell therapy
transcription factor
binding protein
high glucose
diabetic rats
drug induced