Obesity and Psoriatic Arthritis: A Narrative Review.
Anand KumthekarAlexis OgdiePublished in: Rheumatology and therapy (2020)
Patients with psoriatic arthritis (PsA) have a higher burden of cardio-metabolic comorbidities like obesity, hypertension, diabetes, and cardiovascular disease compared to the general population. Adipose tissue is thought to promote a chronic low grade inflammatory state through inflammatory mediators like tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), leptin, and adiponectin. A higher body mass index (BMI) is a risk factor for development of PsA and affects disease activity and response to therapy including both disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor inhibitors (TNFi). Obesity has an impact on the morbidity in PsA, particularly cardiovascular and/or metabolic. Patients with PsA have a higher cardiovascular risk and obesity may have an additive impact on morbidity and mortality. This review explores the relationship between obesity and PsA.
Keyphrases
- insulin resistance
- prostate cancer
- metabolic syndrome
- weight gain
- rheumatoid arthritis
- type diabetes
- weight loss
- adipose tissue
- body mass index
- cardiovascular disease
- high fat diet induced
- disease activity
- low grade
- radical prostatectomy
- systemic lupus erythematosus
- high fat diet
- blood pressure
- oxidative stress
- skeletal muscle
- rheumatoid arthritis patients
- high grade
- physical activity
- risk factors
- coronary artery disease
- cardiovascular risk factors
- bone marrow
- cell therapy
- drug induced