β2-Adrenoceptor Activation Stimulates IL-6 Production via PKA, ERK1/2, Src, and Beta-Arrestin2 Signaling Pathways in Human Bronchial Epithelia.
Rui-Gang ZhangYa NiuKe-Wu PanHao PangChun-Ling ChenChung-Yin YipWing-Hung KoPublished in: Lung (2021)
Our results suggest that activation of the β2-adrenoceptor in 16HBE14o- cells stimulated the PKA/Src/ERK1/2 and/or β-arrestin2 signaling pathways, leading to IL-6 release. Therefore, our data reveal that β2-adrenoceptor signaling plays a role in the immune regulation of human airway epithelia.
Keyphrases
- signaling pathway
- induced apoptosis
- pi k akt
- endothelial cells
- cell cycle arrest
- cell proliferation
- tyrosine kinase
- induced pluripotent stem cells
- epithelial mesenchymal transition
- pluripotent stem cells
- genome wide
- electronic health record
- endoplasmic reticulum stress
- big data
- gene expression
- oxidative stress
- cell death
- deep learning
- dna methylation