Proteomic changes in intracranial blood during human ischemic stroke.

Benton MaglingerJacqueline A FrankChristopher J McLouthAmanda L TroutJill Marie RobertsStephen GrupkeJadwiga Turchan-CholewoAnn M StoweJustin F FraserKeith R Pennypacker

Published in: Journal of neurointerventional surgery (2020)

Evaluation of proteomic changes in the intravascular space of a cerebral infarct in progress in human subjects suggested that changes in proteins such PLTP, fetuin-B (FETUB), and FCN2 may be involved in atherosclerotic changes, and chemokines such as CCL23 are known to play a role in the Th2 autoimmune response. These data provide a scientific springboard for identifying clinically relevant biomarkers for diagnosis/prognosis, and targets for much needed neuroprotective/neuroreparative pharmacotherapies.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
multiple sclerosis
coronary artery
acute myocardial infarction
heart failure
atrial fibrillation
electronic health record
machine learning
liver injury
liver fibrosis
brain injury