The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation.
Brian D FriendMara Bailey-OlsonAlexis MeltonKristin A ShimanoSandhya KharbandaChristine HighamLena E WinestoneJames HuangElliot StieglitzChristopher C DvorakPublished in: Pediatric blood & cancer (2019)
Our data suggest that the decision to use either a TBI or non-TBI regimens in ALL should depend on NGS-MRD status, with conditioning regimens based on TBI reserved for patients that cannot achieve NGS-MRD negativity prior to allogeneic HSCT.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- acute lymphoblastic leukemia
- traumatic brain injury
- young adults
- end stage renal disease
- severe traumatic brain injury
- acute myeloid leukemia
- ejection fraction
- newly diagnosed
- mild traumatic brain injury
- stem cell transplantation
- chronic kidney disease
- peritoneal dialysis
- type diabetes
- big data
- hematopoietic stem cell
- decision making
- adipose tissue
- weight loss
- artificial intelligence
- data analysis