β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.

Shota TanakaAtsuki ImaedaKotaro MatsumotoMakiko MaedaMasanori ObanaYasushi Fujio

Published in: Pharmacology research & perspectives (2021)

β2-adrenergic stimulation post-transcriptionally upregulates the expression of IL-6 by the induction of Arid5a through cAMP/PKA/CREB pathway in adult CFs. β2AR/Arid5a/IL-6 axis could be a therapeutic target against cardiac inflammation.

Keyphrases

binding protein
left ventricular
poor prognosis
oxidative stress
protein kinase
heart failure
extracellular matrix