Comparison of prostate-specific membrane antigen ligands in clinical translation research for diagnosis of prostate cancer.
Sagnik SenguptaMena Asha KrishnanSudeshna ChattopadhyayVenkatesh ChelvamPublished in: Cancer reports (Hoboken, N.J.) (2019)
This report discusses in detail the homing moieties used in the development of targeted diagnostic tools for detection of PCa. The merits and demerits of monoclonal antibodies, small molecule ligands, peptides, and aptamers for imaging of PCa and intraoperative guided surgery are extensively analyzed. Among all, urea-based ligands were found to be most successful in preclinical and clinical trials and show a major promise for future commercialization.
Keyphrases
- prostate cancer
- small molecule
- clinical trial
- radical prostatectomy
- minimally invasive
- high resolution
- multidrug resistant
- protein protein
- patients undergoing
- current status
- randomized controlled trial
- cancer therapy
- big data
- cell therapy
- stem cells
- surgical site infection
- acute coronary syndrome
- quantum dots
- phase iii
- percutaneous coronary intervention
- fluorescence imaging