Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study.

Carley M BoganJessica V KaczmarekJanene M PierceSheau-Chiann ChenKelli L BoydMarion W CalcuttThomas M BridgesCraig W LindsleyJennifer B NadelmannAlbert LiaoTerry HsiehDavid H AbramsonJasmine H FrancisDebra L FriedmanAnn RichmondAnthony B Daniels

Published in: The British journal of ophthalmology (2021)

Taken together, these experiments suggest that intravitreal topotecan monotherapy for the treatment of RB vitreous seeds is non-toxic and effective.

Keyphrases

vascular endothelial growth factor
diabetic retinopathy
combination therapy
age related macular degeneration
oxidative stress
randomized controlled trial
stem cells
open label
cell therapy
double blind
optical coherence tomography
smoking cessation
study protocol