How T'reg-ulate healing of the injured spinal cord?
Simon W F MillingJulia M EdgarPublished in: Immunology (2020)
Regulatory T cells (Tregs) are important for limiting inflammation-dependent damage in neural tissue. However, Tregs have also been shown to inhibit neural repair associated with type 2 (anti-inflammatory/wound healing) immune responses. Recently, it was demonstrated that Sirtuins, a family of proteins that contribute to the control of cellular responses to metabolic stimuli, influence the functions of Tregs. Specifically, SIRT4 was found to suppress the anti-neuroinflammatory activity of Tregs infiltrating the spinal cord following injury; when SIRT4 expression was genetically suppressed, Tregs made more anti-inflammatory factors, IL-10, FoxP3, and transforming growth factor beta (TGFβ). Thus, understanding how the SIRT4-Treg pathway can be manipulated could provide useful avenues to control both pathogenic and neuroprotective immune responses.
Keyphrases
- regulatory t cells
- transforming growth factor
- spinal cord
- oxidative stress
- immune response
- anti inflammatory
- dendritic cells
- epithelial mesenchymal transition
- ischemia reperfusion injury
- spinal cord injury
- wound healing
- neuropathic pain
- poor prognosis
- toll like receptor
- inflammatory response
- signaling pathway
- long non coding rna
- blood brain barrier