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Pathological changes in oral epithelium and the expression of SARS-CoV-2 entry receptors, ACE2 and furin.

Osnat Grinstein-KorenMichal LusthausHilla Tabibian-KeissarIlana KaplanAmos BuchnerRon IlatovMarilena VeredAyelet Zlotogorski-Hurvitz
Published in: PloS one (2024)
Oral mucosa, normal or with epithelial pathologies lacked ACE2 expression. Furin was weak and mainly expressed in dysplastic lesions. Thus, patients with epithelial pathologies do not seem to be at higher risk for SARS-CoV-2 infection. Overall, results show that oral mucosae do not seem to be a major site of SARS-CoV-2 entry and these were discussed vis-à-vis a comprehensive analysis of the literature.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • poor prognosis
  • angiotensin ii
  • angiotensin converting enzyme
  • systematic review
  • binding protein