Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa.

Khaoula Zekri-NecharJosé Javier Zamorano-LeónCarmen RecheManel GinerAna López-de-AndrésRodrigo Jiménez-GarcíaAntonio J López-FarréCarlos Hugo Martínez-Martínez

Published in: Disease markers (2022)

In HPMEC undergoing to preinflammatory condition, COVID-19 S1+S2 spike subunits promoted alterations in mitochondria metabolism suggesting a shift from aerobic towards anaerobic metabolism that was accompanied of high FXa production. Rivaroxaban prevented all the mitochondrial metabolic changes mediated by the present COVID-19 S1 and S2 spike subunits suggesting the involvement of endogenous FXa.

Keyphrases

sars cov
endothelial cells
coronavirus disease
respiratory syndrome coronavirus
oxidative stress
venous thromboembolism
pulmonary hypertension
pulmonary embolism
atrial fibrillation
risk assessment
reactive oxygen species
pluripotent stem cells
heavy metals