Cervical Cancer Evades the Host Immune System Through the Inhibition of Type I Interferon and CXCL9 by LIF.

Ester Bonfill-Teixidor Almudena Neva-Alejo Alexandra Arias Isabel Cuartas Raffaella Iurlaro Ester Planas-Rigol Laura Solé Irene Pecharromán Silvia Cabrera Ángel García David Garcia-Illescas Lluís Espinosa Antonio Gil-Moreno Ana Oaknin Joan Seoane

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our data show that the HPV virus induces the expression of LIF to provide a selective advantage to the tumor cell by generating local immunosuppression via the repression of type I interferon and CXCL9. Combinatory treatment with blocking antibodies against LIF and ICI could be effective against CC expressing high levels of LIF.

Keyphrases

dendritic cells
poor prognosis
high grade
electronic health record
cell therapy
stem cells
immune response
big data
combination therapy
long non coding rna
artificial intelligence