Frequency and Longitudinal Course of Motor Signs In Genetic Frontotemporal Dementia.
Sonja SchöneckerFrancisco Jesús Martinez-MurciaBoris-Stephan RauchmannNicolai FranzmeierCatharina PrixElisabeth WlasichSandra V LoosliKatja BochmannJuan-Manuel Gorriz SaezRobert Jr LaforceSimon DucharmeMaria Carmela TartagliaElizabeth FingerAlexandre de MendonçaIsabel SantanaRaquel Sanchez-ValleFermin MorenoSandro SorbiFabrizio TagliaviniBarbara BorroniMarkus OttoMatthis SynofzikDaniela GalimbertiRik VandenbergheJohn van SwietenChristopher ButlerAlexander GerhardCaroline GraffAdrian DanekJonathan D RohrerMario MasellisJames Benedict RoweJohannes Levinnull nullPublished in: Neurology (2022)
These results indicate the presence of multiple natural clusters of motor signs in genetic FTD, each correlated with specific atrophy patterns. Their motor severity depends on time and the affected gene. These clinico-genetic associations can guide diagnostic evaluations and the design of clinical trials for new disease-modifying and preventive treatments.