A 5-Hydroxymethylcytosine-Based Noninvasive Model for Early Detection of Colorectal Carcinomas and Advanced Adenomas: The METHOD-2 Study.

Wenju Chang Sheng Zhang Baoqing Jia Ke-Feng Ding Zhizhong Pan Guoqiang Su Weiyuan Zhang Tianyu Liu Yun-Shi Zhong Guodong He Li Ren Ye Wei Dongdong Li Xiao-Long Cui Jun Yang Yixiang Shi Marc Bissonnette Chuan He Tripti Khare Jia Fan Jianmin Xu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Genome-wide mapping of 5hmC in cfDNA shows promise as a highly sensitive and specific noninvasive blood test to be integrated into screening programs for improving early detection of colorectal carcinoma and high-risk AA.

Keyphrases

genome wide
dna methylation
public health
high resolution
high grade
big data
fluorescent probe
living cells
artificial intelligence
label free