Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death.

Laura KallayHavva KeskinAlexandra RossManali RupjiOlivia A MoodyXin WangGuanguan LiTaukir AhmedFarjana RashidMichael Rajesh StephenKirsten A CottrillT Austin NuckolsMaxwell XuDeborah E MartinsonFrank TrangheseYanxin PeiJames M CookJeanne KowalskiMichael D TaylorAndrew JenkinsDaniel A Pomeranz KrummelSoma Sengupta

Published in: Journal of neuro-oncology (2019)

GABRA5 expression can serve as a diagnostic biomarker for group 3 tumors, while α5-GABAAR is a therapeutic target for benzodiazepine binding, enhancing an ion imbalance that induces apoptosis.

Keyphrases

cell death
poor prognosis
binding protein
small molecule
signaling pathway
cell cycle arrest
dna binding
long non coding rna